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In temporal lobe epilepsy, levels of astrocytic glutamate transporters in hippocampus are reduced by up to 40%

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AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists

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Given that glutathione is a tripeptide composed of glutamate, glycine, and cysteine, glutamine-derived glutamate and cysteine need to be ligated by glutamate-cysteine ligase (GCL), which itself comprises two separately encoded proteins: a catalytic subunit (GCLC) and a modifier subunit (GCLM) 53,54